Ledipasvir/Sofosbuvir and Cyclosporine Interaction
Drug interaction information between Ledipasvir/Sofosbuvir and Cyclosporine.
Ledipasvir/Sofosbuvir and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ledipasvir/Sofosbuvir and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications do not change how the other drug works or how much of it stays in your body.
FDA Label Information
7.3 Drugs without Clinically Significant Interactions with HARVONI Based on drug interaction studies conducted with the components of HARVONI (ledipasvir or sofosbuvir) or HARVONI, no clinically significant drug interactions have been either observed or are expected when HARVONI is used with the following drugs [see Clinical Pharmacology (12.3) ]: abacavir, atazanavir/ritonavir, cyclosporine, darunavir/ritonavir, dolutegravir, efavirenz, elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide, emtricitabine, lamivudine, methadone, midazolam, oral contraceptives, pravastatin,...
Ledipasvir/Sofosbuvir Also Interacts With
- Atorvastatin moderate
- Rifampin moderate
- Amiodarone moderate
- Rosuvastatin moderate
- Rosuvastatin/Ezetimibe moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Ledipasvir/Sofosbuvir + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Ledipasvir/Sofosbuvir's 22. In the minor band specifically: Ledipasvir/Sofosbuvir has 17 (also Omeprazole, Pravastatin, Warfarin, Verapamil); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Ledipasvir/Sofosbuvir and Cyclosporine?
These medications do not change how the other drug works or how much of it stays in your body.
Cyclosporine carries more major-labeled pairs than Ledipasvir/Sofosbuvir
SPL source-record counts only. This page's band is minor · classes on file: Ledipasvir/Sofosbuvir (NS5A/NS5B Inhibitor (HCV)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Ledipasvir/Sofosbuvir's 0. This page itself is in the minor band, not the major band.
0 major · 5 moderate · 17 minor · 22 total
- Other minor peers for Ledipasvir/Sofosbuvir
- Omeprazole
- Pravastatin
- Warfarin
- Verapamil
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.