Ledipasvir/Sofosbuvir and Atorvastatin Interaction
Drug interaction information between Ledipasvir/Sofosbuvir and Atorvastatin.
Ledipasvir/Sofosbuvir and Atorvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ledipasvir/Sofosbuvir and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Harvoni can increase the amount of atorvastatin in your system, which may lead to severe muscle problems.
FDA Label Information
atorvastatin ↑ atorvastatin Coadministration of HARVONI with atorvastatin may be associated with increased risk of myopathy, including rhabdomyolysis.
Ledipasvir/Sofosbuvir Also Interacts With
- Rifampin moderate
- Amiodarone moderate
- Rosuvastatin moderate
- Rosuvastatin/Ezetimibe moderate
- Omeprazole minor
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Ledipasvir/Sofosbuvir + Atorvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atorvastatin has 36 labeled pairs on file vs Ledipasvir/Sofosbuvir's 22. In the moderate band specifically: Ledipasvir/Sofosbuvir has 5 (also Rifampin, Amiodarone, Rosuvastatin, Rosuvastatin/Ezetimibe); Atorvastatin has 8 (also Cyclosporine, Colchicine, Gemfibrozil, Niacin).
What mechanism field is on file for Ledipasvir/Sofosbuvir and Atorvastatin?
Harvoni can increase the amount of atorvastatin in your system, which may lead to severe muscle problems.
Atorvastatin carries more major-labeled pairs than Ledipasvir/Sofosbuvir
SPL source-record counts only. This page's band is moderate · classes on file: Ledipasvir/Sofosbuvir (NS5A/NS5B Inhibitor (HCV)); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Atorvastatin has 3 major-labeled pairs vs Ledipasvir/Sofosbuvir's 0. This page itself is in the moderate band, not the major band.
0 major · 5 moderate · 17 minor · 22 total
- Other moderate peers for Ledipasvir/Sofosbuvir
- Rifampin
- Amiodarone
- Rosuvastatin
- Rosuvastatin/Ezetimibe
3 major · 8 moderate · 25 minor · 36 total
- Other moderate peers for Atorvastatin
- Cyclosporine
- Colchicine
- Gemfibrozil
- Niacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.