Metoprolol and Fluoxetine Interaction
Drug interaction information between Metoprolol and Fluoxetine.
Metoprolol and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metoprolol and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine blocks the liver from breaking down metoprolol, which can cause the amount of metoprolol in your blood to double.
FDA Label Information
7.3 CYP2D6 Inhibitors Drugs that are strong inhibitors of CYP2D6 such as quinidine, fluoxetine, paroxetine, and propafenone were shown to double metoprolol concentrations.
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Paroxetine minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Metoprolol + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Metoprolol's 18. In the minor band specifically: Metoprolol has 14 (also Paroxetine, Propafenone, Epinephrine, Bupropion); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Metoprolol and Fluoxetine?
Fluoxetine blocks the liver from breaking down metoprolol, which can cause the amount of metoprolol in your blood to double.
Fluoxetine carries more major-labeled pairs than Metoprolol
SPL source-record counts only. This page's band is minor · classes on file: Metoprolol (Beta-Blocker); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Metoprolol's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 14 minor · 18 total
- Other minor peers for Metoprolol
- Paroxetine
- Propafenone
- Epinephrine
- Bupropion
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.