felodipine vs metoprolol
Side-by-side comparison of felodipine and metoprolol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Beta-Blocking Agents A pharmacokinetic study of felodipine in conjunction with metoprolol demonstrated no significant effects on the pharmacokinetics of felodipine. The AUC and C max of metoprolol, however, were increased approximately 31 and 38%, respectively. In controlled clinical trials, however, beta-blockers including metoprolol were concurrently administered with felodipine and were well tolerated.
Recommendation: These drugs are generally safe to take together. Your doctor will monitor you to ensure the combination is working correctly.
Plendil
Lopressor, Toprol-XL
Felodipine is a drug that lowers your blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks.
Metoprolol is a beta-blocker medicine. It can lower blood pressure, reduce chest pain, and improve survival after a heart attack.
Felodipine treats high blood pressure (hypertension). Lowering your blood pressure helps prevent strokes and heart attacks. It's important to also manage other risk factors like cholesterol, diabetes, and smoking. You may need more than one medicine to control your blood pressure.
Metoprolol treats high blood pressure (hypertension). Lowering blood pressure reduces the risk of strokes and heart attacks. It also treats chest pain called angina. After a heart attack, it can help you live longer.
Felodipine is a calcium channel blocker. It works by relaxing and widening your blood vessels. This makes it easier for blood to flow, which lowers blood pressure.
Metoprolol blocks the effects of adrenaline on the heart. This makes the heart beat slower and with less force. As a result, blood pressure is lowered and the heart does not need as much oxygen.
- • Swelling in your ankles or feet
- • Headache
- • Flushing (redness of face)
- • Feeling tired
- • Tiredness
- • Dizziness
- • Depression
- • Shortness of breath
- • Slow heart rate
- Feeling tired 1,050
- Difficulty breathing 953
- Feeling lightheaded 946
- Loose stools 846
- Feeling sick to your stomach 846
- Tiredness 15,963
- Shortness of breath 14,131
- Diarrhea 13,634
- Feeling sick to your stomach 13,392
- Feeling lightheaded 11,697
If you take certain medicines like ketoconazole, itraconazole, or erythromycin, talk to your doctor. These drugs can greatly increase the amount of felodipine in your blood, leading to unwanted effects. Also, if you take anticonvulsants like phenytoin, carbamazepine, or phenobarbital, felodipine may not work as well.
Stopping metoprolol suddenly can make chest pain worse or cause a heart attack. If you have heart failure, it could get worse. If you have asthma or other lung problems, avoid beta-blockers if possible.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if felodipine will harm your unborn baby. Talk to your doctor about breastfeeding while taking felodipine.
Tell your doctor if you are pregnant or plan to become pregnant. Metoprolol can cross the placenta, and may cause low blood pressure, low blood sugar, and a slow heart rate in the newborn. Talk to your doctor about the risks and benefits.
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How to Read This felodipine vs metoprolol Comparison
felodipine is classified in the Calcium Channel Blocker drug class, while metoprolol sits within the Beta-Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, felodipine has 4,641 submissions while metoprolol has 68,817. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to felodipine can increase the amount of metoprolol that stays in your blood. this happens because felodipine changes how the body processes metoprolol.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between felodipine and metoprolol - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.