What the FDA labels say about taking them together
Metoprolol and verapamil
Metoprolol's FDA label of March 3, 2026 names verapamil in its drug interactions section, and verapamil's label names metoprolol too. The verapamil label: “A decrease in metoprolol clearance has been reported when verapamil and metoprolol were administered together.”
Check it at the source: the metoprolol FDA label on DailyMed (effective March 3, 2026, Melinta Therapeutics, LLC); the verapamil FDA label on DailyMed (effective April 6, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the metoprolol label say about verapamil?
Metoprolol label, drug interactionsDigitalis glycosides, clonidine, diltiazem, and verapamil slow atrioventricular conduction and decrease heart rate.
Metoprolol label, warnings and precautionsWorsening cardiac failure may occur. ( 5.2 ) Bronchospastic Disease: Avoid beta-blockers. ( 5.3 ) Concomitant use of glycosides, clonidine, diltiazem and verapamil with beta-blockers can increase the risk of bradycardia.
Lopressor label (Validus Pharmaceuticals LLC, September 14, 2023), drug interactionsDRUG INTERACTIONS Catecholamine-depleting drugs may have an additive effect when given with beta-blocking agents. ( 7.1 ) Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. ( 7.2 ) CYP2D6 Inhibitors are likely to increase metoprolol concentration. ( 7.3 ) Concomitant use of glycosides, clonidine, and diltiazem and verapamil with beta-blockers can increase the risk of bradycardia. ( 7.4 ) Beta-blockers including metoprolol, may exacerbate the rebound hypertension that can follow the withdrawal of clonidine.
Kapspargo label (Sun Pharmaceutical Industries, Inc., April 12, 2023), warnings and precautionsConcomitant use of glycosides, clonidine, diltiazem and verapamil with beta-blockers can increase the risk of bradycardia.
Source: FDA drug label (Lopressor, NDA017963), Validus Pharmaceuticals LLC, effective September 14, 2023 (SPL set 0283bc9d-6998-493a-824a-d4c85f704111), via openFDA
Source: FDA drug label (Kapspargo, NDA210428), Sun Pharmaceutical Industries, Inc., effective April 12, 2023 (SPL set 9cfa55b4-15c6-40f7-b6e5-41096ee51bfc), via openFDA
Source: FDA drug label (TOPROL XL), Melinta Therapeutics, LLC, effective March 3, 2026 (SPL set 496ddfaa-7c9c-4888-b747-a210249b367a), via openFDA; the full label on DailyMed
What does the verapamil label say about metoprolol?
Verapamil label, drug interactionsA decrease in metoprolol and propranolol clearance has been observed when either drug is administered concomitantly with verapamil.
Verapamil Hydrochloride label (Wilshire Pharmaceuticals, Inc., November 27, 2024), drug interactionsA decrease in metoprolol clearance has been reported when verapamil and metoprolol were administered together.
Source: FDA drug label (Verapamil Hydrochloride, NDA019614), Wilshire Pharmaceuticals, Inc., effective November 27, 2024 (SPL set f9399858-fd7a-4b73-8759-3e5bf3af2666), via openFDA
Source: FDA drug label (Verapamil hydrochloride), Zydus Pharmaceuticals (USA) Inc., effective April 6, 2026 (SPL set e19ab8d8-dae5-489d-9805-7e7407bea06d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Metoprolol | Verapamil | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart failure, Heart attack and coronary artery disease | High blood pressure, Atrial fibrillation, Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.085 per tablet 100 mg tablet | $0.191 per tablet 180 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once