Metoprolol and Propafenone Interaction
Drug interaction information between Metoprolol and Propafenone.
Metoprolol and Propafenone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metoprolol and Propafenone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Propafenone prevents your body from clearing metoprolol, which can lead to twice as much metoprolol in your bloodstream.
FDA Label Information
7.3 CYP2D6 Inhibitors Drugs that are strong inhibitors of CYP2D6 such as quinidine, fluoxetine, paroxetine, and propafenone were shown to double metoprolol concentrations.
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
Propafenone Also Interacts With
- Nirmatrelvir/Ritonavir major
- Amiodarone moderate
- Fluoxetine moderate
- Nebivolol moderate
- Ketoconazole minor
Frequently Asked Questions
What SPL severity band is on file for Metoprolol + Propafenone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propafenone has 26 labeled pairs on file vs Metoprolol's 18. In the minor band specifically: Metoprolol has 14 (also Fluoxetine, Paroxetine, Epinephrine, Bupropion); Propafenone has 22 (also Ketoconazole, Erythromycin, Desipramine, Cimetidine).
What mechanism field is on file for Metoprolol and Propafenone?
Propafenone prevents your body from clearing metoprolol, which can lead to twice as much metoprolol in your bloodstream.
Propafenone's labeled portfolio outnumbers Metoprolol
SPL source-record counts only. This page's band is minor · classes on file: Metoprolol (Beta-Blocker); Propafenone (Class IC Antiarrhythmic).
1 major · 3 moderate · 14 minor · 18 total
- Other minor peers for Metoprolol
- Fluoxetine
- Paroxetine
- Epinephrine
- Bupropion
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Propafenone
- Ketoconazole
- Erythromycin
- Desipramine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.