Metoprolol and Epinephrine Interaction
Drug interaction information between Metoprolol and Epinephrine.
Metoprolol and Epinephrine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metoprolol and Epinephrine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metoprolol blocks the receptors that epinephrine needs to work, which can make epinephrine less effective during a severe allergic reaction.
FDA Label Information
( 7.1 ) Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. 7.2 Epinephrine While taking beta-blockers, patients with a history of severe anaphylactic reactions to a variety of allergens may be more reactive to repeated challenge and may be unresponsive to the usual doses of epinephrine used to treat an allergic reaction.
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
Epinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Digoxin moderate
- Imipramine moderate
- Levothyroxine minor
Frequently Asked Questions
What SPL severity band is on file for Metoprolol + Epinephrine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Epinephrine has 28 labeled pairs on file vs Metoprolol's 18. In the minor band specifically: Metoprolol has 14 (also Fluoxetine, Paroxetine, Propafenone, Bupropion); Epinephrine has 24 (also Levothyroxine, Clonidine, Theophylline, Oxytocin).
What mechanism field is on file for Metoprolol and Epinephrine?
Metoprolol blocks the receptors that epinephrine needs to work, which can make epinephrine less effective during a severe allergic reaction.
Epinephrine's labeled portfolio outnumbers Metoprolol
SPL source-record counts only. This page's band is minor · classes on file: Metoprolol (Beta-Blocker); Epinephrine (Adrenergic Agonist).
1 major · 3 moderate · 14 minor · 18 total
- Other minor peers for Metoprolol
- Fluoxetine
- Paroxetine
- Propafenone
- Bupropion
1 major · 3 moderate · 24 minor · 28 total
- Other minor peers for Epinephrine
- Levothyroxine
- Clonidine
- Theophylline
- Oxytocin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.