Metoprolol and Clonidine Interaction
Drug interaction information between Metoprolol and Clonidine.
Metoprolol and Clonidine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Metoprolol and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs work to slow down your heart rate, which can cause your heart to beat too slowly when taken together. Additionally, stopping one of these drugs suddenly can cause a dangerous rise in blood pressure.
FDA Label Information
( 7.3 ) Concomitant use of glycosides, clonidine, and diltiazem and verapamil with beta-blockers can increase the risk of bradycardia. ( 7.4 ) Beta-blockers including metoprolol, may exacerbate the rebound hypertension that can follow the withdrawal of clonidine. 7.4 Negative Chronotropes Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate.
Metoprolol Also Interacts With
- Theophylline major
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
- Paroxetine minor
Clonidine Also Interacts With
- Carvedilol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Metoprolol + Clonidine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Metoprolol's 18. In the moderate band specifically: Metoprolol has 3 (also Diltiazem, Verapamil); Clonidine has 4 (also Carvedilol, Repaglinide, Sotalol).
What mechanism field is on file for Metoprolol and Clonidine?
Both drugs work to slow down your heart rate, which can cause your heart to beat too slowly when taken together. Additionally, stopping one of these drugs suddenly can cause a dangerous rise in blood pressure.
Metoprolol carries more major-labeled pairs than Clonidine
SPL source-record counts only. This page's band is moderate · classes on file: Metoprolol (Beta-Blocker); Clonidine (Central Alpha-2 Agonist).
Metoprolol has 1 major-labeled pair vs Clonidine's 0. This page itself is in the moderate band, not the major band.
1 major · 3 moderate · 14 minor · 18 total
0 major · 4 moderate · 25 minor · 29 total
- Other moderate peers for Clonidine
- Carvedilol
- Repaglinide
- Sotalol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.