What the FDA labels say about taking them together
Clonidine and metoprolol
Metoprolol's FDA label of March 3, 2026 names clonidine in its drug interactions section; clonidine's label does not name metoprolol itself but warns about its class (Beta blockers). The metoprolol label: “… may exacerbate the rebound hypertension that can follow the withdrawal of clonidine.”
Check it at the source: the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.); the metoprolol FDA label on DailyMed (effective March 3, 2026, Melinta Therapeutics, LLC).
What does the clonidine label say about metoprolol?
Clonidine's label does not name metoprolol itself; it warns about its class (Beta blockers):
Clonidine label, drug interactionsMonitor heart rate in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction, e.g. , digitalis, calcium channel blockers and beta-blockers.
Clonidine label, warningsThe likelihood of such reactions to discontinuation of clonidine therapy appears to be greater after administration of higher doses or continuation of concomitant beta-blocker treatment and special caution is therefore advised in these situations.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
What does the metoprolol label say about clonidine?
Metoprolol label, drug interactionsDRUG INTERACTIONS Catecholamine-depleting drugs may have an additive effect when given with beta-blocking agents. ( 7.1 ) CYP2D6 Inhibitors are likely to increase metoprolol concentration. ( 7.2 ) Beta-blockers including metoprolol, may exacerbate the rebound hypertension that can follow the withdrawal of clonidine.
Metoprolol label, warnings and precautionsWorsening cardiac failure may occur. ( 5.2 ) Bronchospastic Disease: Avoid beta-blockers. ( 5.3 ) Concomitant use of glycosides, clonidine, diltiazem and verapamil with beta-blockers can increase the risk of bradycardia.
Lopressor label (Validus Pharmaceuticals LLC, September 14, 2023), drug interactionsDRUG INTERACTIONS Catecholamine-depleting drugs may have an additive effect when given with beta-blocking agents. ( 7.1 ) Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. ( 7.2 ) CYP2D6 Inhibitors are likely to increase metoprolol concentration. ( 7.3 ) Concomitant use of glycosides, clonidine, and diltiazem and verapamil with beta-blockers can increase the risk of bradycardia. ( 7.4 ) Beta-blockers including metoprolol, may exacerbate the rebound hypertension that can follow the withdrawal of clonidine.
Kapspargo label (Sun Pharmaceutical Industries, Inc., April 12, 2023), drug interactionsBeta-blockers including metoprolol, may exacerbate the rebound hypertension that can follow the withdrawal of clonidine.
Kapspargo label (Sun Pharmaceutical Industries, Inc., April 12, 2023), warnings and precautionsConcomitant use of glycosides, clonidine, diltiazem and verapamil with beta-blockers can increase the risk of bradycardia.
Source: FDA drug label (Lopressor, NDA017963), Validus Pharmaceuticals LLC, effective September 14, 2023 (SPL set 0283bc9d-6998-493a-824a-d4c85f704111), via openFDA
Source: FDA drug label (Kapspargo, NDA210428), Sun Pharmaceutical Industries, Inc., effective April 12, 2023 (SPL set 9cfa55b4-15c6-40f7-b6e5-41096ee51bfc), via openFDA
Source: FDA drug label (TOPROL XL), Melinta Therapeutics, LLC, effective March 3, 2026 (SPL set 496ddfaa-7c9c-4888-b747-a210249b367a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonidine | Metoprolol | |
|---|---|---|
| Labeled for | High blood pressure, ADHD, Pain | High blood pressure, Angina, Heart failure, Heart attack and coronary artery disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0241 per tablet 0.1 mg tablet | $0.085 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once