Metoprolol and Theophylline Interaction
Drug interaction information between Metoprolol and Theophylline.
Metoprolol and Theophylline have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Metoprolol and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metoprolol is a beta-blocker that can block the airway-opening effects of theophylline. This combination can make it harder for you to breathe and may change the amount of medicine in your blood.
FDA Label Information
albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...
Metoprolol Also Interacts With
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
- Paroxetine minor
Theophylline Also Interacts With
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
- Prednisone major
Frequently Asked Questions
What SPL severity band is on file for Metoprolol + Theophylline?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Metoprolol's 18. In the major band specifically: Metoprolol has 1; Theophylline has 27 (also Albuterol, Omeprazole, Amoxicillin, Famotidine).
What mechanism field is on file for Metoprolol and Theophylline?
Metoprolol is a beta-blocker that can block the airway-opening effects of theophylline. This combination can make it harder for you to breathe and may change the amount of medicine in your blood.
Theophylline carries more major-labeled pairs than Metoprolol
SPL source-record counts only. This page's band is major · classes on file: Metoprolol (Beta-Blocker); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Metoprolol's 1.
1 major · 3 moderate · 14 minor · 18 total
Metoprolol has no other major-band peer in this dataset besides Theophylline.
27 major · 5 moderate · 54 minor · 86 total
- Other major peers for Theophylline
- Albuterol
- Omeprazole
- Amoxicillin
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.