Dexlansoprazole and Ketoconazole Interaction
Drug interaction information between Dexlansoprazole and Ketoconazole.
Dexlansoprazole and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dexlansoprazole and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine lowers stomach acid, which ketoconazole needs to dissolve and get into your bloodstream. Without enough acid, your body may not absorb enough of the antifungal medicine to work properly.
FDA Label Information
Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole/itraconazole) Clinical Impact: Dexlansoprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity.
Dexlansoprazole Also Interacts With
- Rifampin moderate
- Warfarin minor
- Methotrexate minor
- Itraconazole minor
- Voriconazole minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Dexlansoprazole + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Dexlansoprazole's 8. In the minor band specifically: Dexlansoprazole has 7 (also Warfarin, Methotrexate, Itraconazole, Voriconazole); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Dexlansoprazole and Ketoconazole?
This medicine lowers stomach acid, which ketoconazole needs to dissolve and get into your bloodstream. Without enough acid, your body may not absorb enough of the antifungal medicine to work properly.
Ketoconazole carries more major-labeled pairs than Dexlansoprazole
SPL source-record counts only. This page's band is minor · classes on file: Dexlansoprazole (Proton Pump Inhibitor (PPI)); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Dexlansoprazole's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Dexlansoprazole
- Warfarin
- Methotrexate
- Itraconazole
- Voriconazole
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.