Dexlansoprazole and Methotrexate Interaction
Drug interaction information between Dexlansoprazole and Methotrexate.
Dexlansoprazole and Methotrexate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dexlansoprazole and Methotrexate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dexlansoprazole can cause methotrexate to stay in your body longer and reach higher levels than normal. This can increase the risk of harmful side effects from the methotrexate.
FDA Label Information
Methotrexate Clinical Impact: Concomitant use of PPIs with methotrexate (primarily at high dose) may elevate and prolong serum concentrations of methotrexate and/or its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. No formal drug interaction studies of high-dose methotrexate with PPIs have been conducted [see Warnings and Precautions (5.10)] . Intervention: A temporary withdrawal of dexlansoprazole may be considered in some patients receiving high-dose methotrexate.
Dexlansoprazole Also Interacts With
- Rifampin moderate
- Warfarin minor
- Ketoconazole minor
- Itraconazole minor
- Voriconazole minor
Methotrexate Also Interacts With
- Celecoxib moderate
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Frequently Asked Questions
What SPL severity band is on file for Dexlansoprazole + Methotrexate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methotrexate has 38 labeled pairs on file vs Dexlansoprazole's 8. In the minor band specifically: Dexlansoprazole has 7 (also Warfarin, Ketoconazole, Itraconazole, Voriconazole); Methotrexate has 26 (also Aspirin, Folic Acid, Probenecid, Phenytoin).
What mechanism field is on file for Dexlansoprazole and Methotrexate?
Dexlansoprazole can cause methotrexate to stay in your body longer and reach higher levels than normal. This can increase the risk of harmful side effects from the methotrexate.
Methotrexate's labeled portfolio outnumbers Dexlansoprazole
SPL source-record counts only. This page's band is minor · classes on file: Dexlansoprazole (Proton Pump Inhibitor (PPI)); Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)).
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Dexlansoprazole
- Warfarin
- Ketoconazole
- Itraconazole
- Voriconazole
0 major · 12 moderate · 26 minor · 38 total
- Other minor peers for Methotrexate
- Aspirin
- Folic Acid
- Probenecid
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.