Clopidogrel and Bupropion Interaction
Drug interaction information between Clopidogrel and Bupropion.
Clopidogrel and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clopidogrel and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clopidogrel changes how your body processes bupropion, which can lead to higher levels of the drug in your system.
FDA Label Information
Inhibitors of CYP2B6 Ticlopidine and Clopidogrel: Concomitant treatment with these drugs can increase bupropion exposures but decrease hydroxybupropion exposure. Based on clinical response, dosage adjustment of bupropion hydrochloride extended-release tablets (XL) may be necessary when coadministered with CYP2B6 inhibitors (e.g., ticlopidine or clopidogrel) [see Clinical Pharmacology (12.3) ].
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Clopidogrel + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Clopidogrel's 19. In the minor band specifically: Clopidogrel has 10 (also Morphine, Repaglinide, Lansoprazole, Dexlansoprazole); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Venlafaxine).
What mechanism field is on file for Clopidogrel and Bupropion?
Clopidogrel changes how your body processes bupropion, which can lead to higher levels of the drug in your system.
Bupropion carries more major-labeled pairs than Clopidogrel
SPL source-record counts only. This page's band is minor · classes on file: Clopidogrel (Antiplatelet Agent); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Bupropion has 1 major-labeled pair vs Clopidogrel's 0. This page itself is in the minor band, not the major band.
0 major · 9 moderate · 10 minor · 19 total
- Other minor peers for Clopidogrel
- Morphine
- Repaglinide
- Lansoprazole
- Dexlansoprazole
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.