Dexlansoprazole and Warfarin Interaction
Drug interaction information between Dexlansoprazole and Warfarin.
Dexlansoprazole and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dexlansoprazole and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dexlansoprazole can increase the blood-thinning effects of warfarin. This makes your blood take longer to clot and increases the risk of bleeding.
FDA Label Information
Warfarin Clinical Impact: Increased INR and prothrombin time in patients receiving PPIs and warfarin concomitantly. Dose adjustment of warfarin may be needed to maintain target INR range. See prescribing information for warfarin.
Dexlansoprazole Also Interacts With
- Rifampin moderate
- Methotrexate minor
- Ketoconazole minor
- Itraconazole minor
- Voriconazole minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Dexlansoprazole + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Dexlansoprazole's 8. In the minor band specifically: Dexlansoprazole has 7 (also Methotrexate, Ketoconazole, Itraconazole, Voriconazole); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Dexlansoprazole and Warfarin?
Dexlansoprazole can increase the blood-thinning effects of warfarin. This makes your blood take longer to clot and increases the risk of bleeding.
Warfarin carries more major-labeled pairs than Dexlansoprazole
SPL source-record counts only. This page's band is minor · classes on file: Dexlansoprazole (Proton Pump Inhibitor (PPI)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Dexlansoprazole's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Dexlansoprazole
- Methotrexate
- Ketoconazole
- Itraconazole
- Voriconazole
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.