Dexlansoprazole and Rifampin Interaction
Drug interaction information between Dexlansoprazole and Rifampin.
Dexlansoprazole and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dexlansoprazole and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin can cause your body to clear dexlansoprazole much faster than normal, making the stomach medicine less effective. This prevents the drug from working well to treat your symptoms.
FDA Label Information
John’s Wort, rifampin : Avoid concomitant use with dexlansoprazole.
Dexlansoprazole Also Interacts With
- Warfarin minor
- Methotrexate minor
- Ketoconazole minor
- Itraconazole minor
- Voriconazole minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Dexlansoprazole + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Dexlansoprazole's 8. In the moderate band specifically: Dexlansoprazole has 1; Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Dexlansoprazole and Rifampin?
Rifampin can cause your body to clear dexlansoprazole much faster than normal, making the stomach medicine less effective. This prevents the drug from working well to treat your symptoms.
Rifampin carries more major-labeled pairs than Dexlansoprazole
SPL source-record counts only. This page's band is moderate · classes on file: Dexlansoprazole (Proton Pump Inhibitor (PPI)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Dexlansoprazole's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 7 minor · 8 total
Dexlansoprazole has no other moderate-band peer in this dataset besides Rifampin.
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.