What the FDA labels say about taking them together
Dexlansoprazole and rifampin
Dexlansoprazole's FDA label of February 17, 2025 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name dexlansoprazole. The dexlansoprazole label: “Decreased exposure of dexlansoprazole when used concomitantly with strong inducers.”
Check it at the source: the dexlansoprazole FDA label on DailyMed (effective February 17, 2025, Takeda Pharmaceuticals America, Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the dexlansoprazole label say about rifampin?
Dexlansoprazole label, drug interactionsClinical Impact: Decreased exposure of dexlansoprazole when used concomitantly with strong inducers. Intervention: St. John's Wort, rifampin: Avoid concomitant use with DEXILANT. Ritonavir-containing products: See prescribing information. CYP2C19 or CYP3A4 Inhibitors
Source: FDA drug label (Dexilant), Takeda Pharmaceuticals America, Inc., effective February 17, 2025 (SPL set 9819f033-3bbe-442e-8e92-45fec77b237d), via openFDA; the full label on DailyMed
What does the rifampin label say about dexlansoprazole?
Rifampin's label (effective February 11, 2026) does not name dexlansoprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dexlansoprazole | Rifampin | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $3.71 per capsule 60 mg capsule | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once