clopidogrel vs dexlansoprazole
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Side-by-side comparison of clopidogrel and dexlansoprazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Dexlansoprazole, lansoprazole, and pantoprazole had less effect on the antiplatelet activity of clopidogrel than did omeprazole or esomeprazole [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ].
Plavix
Dexilant
Clopidogrel is a drug that helps to prevent blood clots. It is used to lower your risk of heart attack and stroke.
Dexlansoprazole (Dexilant) is a medicine that lowers stomach acid. It belongs to a class of drugs called proton pump inhibitors (PPIs).
Clopidogrel is used to prevent heart attack and stroke in adults. It is for people who have had a recent heart attack or stroke. It is also for people with peripheral arterial disease (poor circulation). Clopidogrel can also help people with chest pain or certain heart problems.
This medicine can help heal damage to your esophagus (the tube connecting your mouth to your stomach). It can also help with heartburn caused by acid reflux. Dexlansoprazole can also treat heartburn from GERD, a condition where stomach acid flows back into your esophagus.
Clopidogrel keeps blood platelets from sticking together and forming clots. It blocks a substance that causes platelets to clump. This helps blood flow more freely through your body.
Dexlansoprazole works by reducing the amount of acid your stomach makes. It does this by blocking a specific system in your stomach cells. This helps to heal damage caused by stomach acid.
- • Bleeding
- • Diarrhea
- • Abdominal pain
- • Nausea
- • Upper respiratory tract infection
- • Vomiting
- Dyspnoea 9,917
- Myocardial Infarction 9,459
- Fatigue 8,479
- Gastrointestinal Haemorrhage 8,202
- Nausea 7,881
- Chronic Kidney Disease 16,100
- Acute Kidney Injury 7,791
- Renal Failure 6,721
- End Stage Renal Disease 4,842
- Renal Injury 4,339
This drug may not work well for people with certain genes. If you have two copies of a certain gene, clopidogrel may not prevent clots as well. Your doctor may consider a different medicine for you.
Dexlansoprazole may hide signs of stomach cancer, so tell your doctor if your symptoms don't improve. It can also cause kidney problems, severe diarrhea from a Clostridium difficile infection, and bone fractures with long-term use. Some people may have severe skin reactions or lupus. Long-term use may also lead to low vitamin B12 or magnesium levels.
Tell your doctor if you are pregnant or plan to become pregnant. Clopidogrel may increase bleeding during labor and delivery. Talk to your doctor about the risks and benefits of taking this medicine while pregnant or breastfeeding.
Based on animal studies, this medicine may harm a developing baby's bones. Talk to your doctor if you are pregnant or plan to become pregnant.
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How to Read This clopidogrel vs dexlansoprazole Comparison
clopidogrel is classified in the Antiplatelet Agent drug class, while dexlansoprazole sits within the Proton Pump Inhibitor (PPI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, clopidogrel has 43,938 submissions while dexlansoprazole has 39,793. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to dexlansoprazole may slightly reduce clopidogrel's effectiveness, but it does so less than other common stomach acid medicines.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for clopidogrel or dexlansoprazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.