Bupropion and Venlafaxine Interaction
Drug interaction information between Bupropion and Venlafaxine.
Bupropion and Venlafaxine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bupropion and Venlafaxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Bupropion slows down the liver's ability to clear venlafaxine, which can increase the amount of medicine in your blood.
FDA Label Information
( 7.1 ) Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). Such drugs include certain antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotics (e.g., haloperidol, risperidone, and thioridazine), beta-blockers...
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Venlafaxine Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Metoprolol minor
- Fluoxetine minor
- Alprazolam minor
Frequently Asked Questions
What SPL severity band is on file for Bupropion + Venlafaxine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Venlafaxine's 22. In the minor band specifically: Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel); Venlafaxine has 20 (also Metoprolol, Fluoxetine, Alprazolam, Warfarin).
What mechanism field is on file for Bupropion and Venlafaxine?
Bupropion slows down the liver's ability to clear venlafaxine, which can increase the amount of medicine in your blood.
Bupropion carries more major-labeled pairs than Venlafaxine
SPL source-record counts only. This page's band is minor · classes on file: Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)); Venlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
Bupropion has 1 major-labeled pair vs Venlafaxine's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
0 major · 2 moderate · 20 minor · 22 total
- Other minor peers for Venlafaxine
- Metoprolol
- Fluoxetine
- Alprazolam
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.