Amphotericin B and Fluconazole Interaction
Drug interaction information between Amphotericin B and Fluconazole.
Amphotericin B and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amphotericin B and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs can sometimes work against each other depending on the type of fungus being treated. This means they might be less effective when used together than when used alone.
FDA Label Information
Amphotericin B : Concurrent administration of fluconazole and amphotericin B in infected normal and immunosuppressed mice showed the following results: a small additive antifungal effect in systemic infection with Candida albicans , no interaction in intracranial infection with Cryptococcus neoformans , and antagonism of the two drugs in systemic infection with A.
Amphotericin B Also Interacts With
- Cidofovir major
- Ganciclovir moderate
- Valganciclovir moderate
- Ketoconazole minor
- Anidulafungin minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Amphotericin B + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Amphotericin B's 12. In the minor band specifically: Amphotericin B has 9 (also Ketoconazole, Anidulafungin, Dexamethasone, Dronabinol); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Amphotericin B and Fluconazole?
These two drugs can sometimes work against each other depending on the type of fungus being treated. This means they might be less effective when used together than when used alone.
Fluconazole carries more major-labeled pairs than Amphotericin B
SPL source-record counts only. This page's band is minor · classes on file: Amphotericin B (Polyene Antifungal); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Amphotericin B's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 9 minor · 12 total
- Other minor peers for Amphotericin B
- Ketoconazole
- Anidulafungin
- Dexamethasone
- Dronabinol
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.