Amphotericin B and Ketoconazole Interaction
Drug interaction information between Amphotericin B and Ketoconazole.
Amphotericin B and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amphotericin B and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two antifungal medicines together might make the fungus harder to kill and resistant to the treatment.
FDA Label Information
Azoles (e.g., ketoconazole, miconazole, clotrimazole, fluconazole, etc.) In vitro and in vivo animal studies of the combination of amphotericin B and imidazoles suggest that imidazoles may induce fungal resistance to amphotericin B.
Amphotericin B Also Interacts With
- Cidofovir major
- Ganciclovir moderate
- Valganciclovir moderate
- Anidulafungin minor
- Dexamethasone minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Amphotericin B + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Amphotericin B's 12. In the minor band specifically: Amphotericin B has 9 (also Anidulafungin, Dexamethasone, Dronabinol, Fluconazole); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Apixaban).
What mechanism field is on file for Amphotericin B and Ketoconazole?
Using these two antifungal medicines together might make the fungus harder to kill and resistant to the treatment.
Ketoconazole carries more major-labeled pairs than Amphotericin B
SPL source-record counts only. This page's band is minor · classes on file: Amphotericin B (Polyene Antifungal); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Amphotericin B's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 9 minor · 12 total
- Other minor peers for Amphotericin B
- Anidulafungin
- Dexamethasone
- Dronabinol
- Fluconazole
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.