Amphotericin B and Dexamethasone Interaction
Drug interaction information between Amphotericin B and Dexamethasone.
Amphotericin B and Dexamethasone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amphotericin B and Dexamethasone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause your body to lose too much potassium. Having very low potassium levels can lead to serious heart problems.
FDA Label Information
Amphotericin B injection and potassium-depleting agents: When corticosteroids are administered concomitantly with potassium-depleting agents (e.g., amphotericin B, diuretics), patients should be observed closely for development of hypokalemia. In addition, there have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure.
Amphotericin B Also Interacts With
- Cidofovir major
- Ganciclovir moderate
- Valganciclovir moderate
- Ketoconazole minor
- Anidulafungin minor
Dexamethasone Also Interacts With
- Aspirin moderate
- Ketoconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Warfarin minor
- Cyclosporine minor
Frequently Asked Questions
What SPL severity band is on file for Amphotericin B + Dexamethasone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dexamethasone has 21 labeled pairs on file vs Amphotericin B's 12. In the minor band specifically: Amphotericin B has 9 (also Ketoconazole, Anidulafungin, Dronabinol, Fluconazole); Dexamethasone has 18 (also Warfarin, Cyclosporine, Hydrocortisone, Erythromycin).
What mechanism field is on file for Amphotericin B and Dexamethasone?
Both drugs can cause your body to lose too much potassium. Having very low potassium levels can lead to serious heart problems.
Amphotericin B carries more major-labeled pairs than Dexamethasone
SPL source-record counts only. This page's band is minor · classes on file: Amphotericin B (Polyene Antifungal); Dexamethasone (Corticosteroid).
Amphotericin B has 1 major-labeled pair vs Dexamethasone's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 9 minor · 12 total
- Other minor peers for Amphotericin B
- Ketoconazole
- Anidulafungin
- Dronabinol
- Fluconazole
0 major · 3 moderate · 18 minor · 21 total
- Other minor peers for Dexamethasone
- Warfarin
- Cyclosporine
- Hydrocortisone
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.