Amphotericin B and Dronabinol Interaction
Drug interaction information between Amphotericin B and Dronabinol.
Amphotericin B and Dronabinol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amphotericin B and Dronabinol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs compete for the same spots on proteins in the blood. This can cause more of the amphotericin B to be active in the body than usual.
FDA Label Information
(7.3) Highly protein-bound drugs: Potential for displacement of other drugs from plasma proteins; monitor for adverse reactions to concomitant highly protein-bound drugs and narrow therapeutic index drugs (e.g., warfarin, cyclosporine, amphotericin B) when initiating or increasing the dosage of dronabinol capsules. Although this displacement has not been confirmed in vivo , monitor patients for increased adverse reactions to narrow therapeutic index drugs that are highly protein-bound (e.g., warfarin, cyclosporine, amphotericin B) when initiating treatment or increasing the dosage of...
Amphotericin B Also Interacts With
- Cidofovir major
- Ganciclovir moderate
- Valganciclovir moderate
- Ketoconazole minor
- Anidulafungin minor
Dronabinol Also Interacts With
- Warfarin minor
- Ketoconazole minor
- Fluconazole minor
- Cyclosporine minor
- Erythromycin minor
Frequently Asked Questions
What SPL severity band is on file for Amphotericin B + Dronabinol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amphotericin B has 12 labeled pairs on file vs Dronabinol's 9. In the minor band specifically: Amphotericin B has 9 (also Ketoconazole, Anidulafungin, Dexamethasone, Fluconazole); Dronabinol has 9 (also Warfarin, Ketoconazole, Fluconazole, Cyclosporine).
What mechanism field is on file for Amphotericin B and Dronabinol?
Both drugs compete for the same spots on proteins in the blood. This can cause more of the amphotericin B to be active in the body than usual.
Amphotericin B carries more major-labeled pairs than Dronabinol
SPL source-record counts only. This page's band is minor · classes on file: Amphotericin B (Polyene Antifungal); Dronabinol (Cannabinoid Antiemetic).
Amphotericin B has 1 major-labeled pair vs Dronabinol's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 9 minor · 12 total
- Other minor peers for Amphotericin B
- Ketoconazole
- Anidulafungin
- Dexamethasone
- Fluconazole
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Dronabinol
- Warfarin
- Ketoconazole
- Fluconazole
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.