Amphotericin B and Cidofovir Interaction
Drug interaction information between Amphotericin B and Cidofovir.
Amphotericin B and Cidofovir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Amphotericin B and Cidofovir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause damage to the kidneys. Combining them makes kidney injury much more likely.
FDA Label Information
Nephrotoxic agents Concomitant administration of cidofovir injection and agents with nephrotoxic potential [e.g., intravenous aminoglycosides (e.g., tobramycin, gentamicin, and amikacin), amphotericin B, foscarnet, intravenous pentamidine, vancomycin, and nonsteroidal anti-inflammatory agents] is contraindicated.
Amphotericin B Also Interacts With
- Ganciclovir moderate
- Valganciclovir moderate
- Ketoconazole minor
- Anidulafungin minor
- Dexamethasone minor
Cidofovir Also Interacts With
- Vancomycin major
- Gentamicin major
- Tobramycin major
- Amikacin major
- Furosemide minor
Frequently Asked Questions
What SPL severity band is on file for Amphotericin B + Cidofovir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cidofovir has 16 labeled pairs on file vs Amphotericin B's 12. In the major band specifically: Amphotericin B has 1; Cidofovir has 5 (also Vancomycin, Gentamicin, Tobramycin, Amikacin).
What mechanism field is on file for Amphotericin B and Cidofovir?
Both drugs can cause damage to the kidneys. Combining them makes kidney injury much more likely.
Cidofovir carries more major-labeled pairs than Amphotericin B
SPL source-record counts only. This page's band is major · classes on file: Amphotericin B (Polyene Antifungal); Cidofovir (Antiviral (Nucleotide Analog)).
Cidofovir has 5 major-labeled pairs vs Amphotericin B's 1.
1 major · 2 moderate · 9 minor · 12 total
Amphotericin B has no other major-band peer in this dataset besides Cidofovir.
5 major · 0 moderate · 11 minor · 16 total
- Other major peers for Cidofovir
- Vancomycin
- Gentamicin
- Tobramycin
- Amikacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.