Amphotericin B and Valganciclovir Interaction
Drug interaction information between Amphotericin B and Valganciclovir.
Amphotericin B and Valganciclovir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amphotericin B and Valganciclovir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can be hard on the kidneys, and using them at the same time increases the chance of kidney injury.
FDA Label Information
Cyclosporine or amphotericin B Unknown Monitor renal function when valganciclovir is coadministered with cyclosporine or amphotericin B because of potential increase in serum creatinine [see Warnings and Precautions (5.2)]. ( 7 ) Cyclosporine or amphotericin B: When coadministered with valganciclovir, the risk of nephrotoxicity may be increased.
Amphotericin B Also Interacts With
- Cidofovir major
- Ganciclovir moderate
- Ketoconazole minor
- Anidulafungin minor
- Dexamethasone minor
Valganciclovir Also Interacts With
- Cyclosporine moderate
- Trimethoprim minor
- Ganciclovir minor
- Probenecid minor
- Bictegravir/Emtricitabine/Tenofovir minor
Frequently Asked Questions
What SPL severity band is on file for Amphotericin B + Valganciclovir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amphotericin B has 12 labeled pairs on file vs Valganciclovir's 8. In the moderate band specifically: Amphotericin B has 2 (also Ganciclovir); Valganciclovir has 2 (also Cyclosporine).
What mechanism field is on file for Amphotericin B and Valganciclovir?
Both of these drugs can be hard on the kidneys, and using them at the same time increases the chance of kidney injury.
Amphotericin B carries more major-labeled pairs than Valganciclovir
SPL source-record counts only. This page's band is moderate · classes on file: Amphotericin B (Polyene Antifungal); Valganciclovir (Antiviral (Nucleoside Analog)).
Amphotericin B has 1 major-labeled pair vs Valganciclovir's 0. This page itself is in the moderate band, not the major band.
1 major · 2 moderate · 9 minor · 12 total
- Other moderate peers for Amphotericin B
- Ganciclovir
0 major · 2 moderate · 6 minor · 8 total
- Other moderate peers for Valganciclovir
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.