Amphotericin B and Ganciclovir Interaction
Drug interaction information between Amphotericin B and Ganciclovir.
Amphotericin B and Ganciclovir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amphotericin B and Ganciclovir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can be toxic to the kidneys when used at the same time. This combination may lead to a rise in serum creatinine levels, indicating kidney stress.
FDA Label Information
Cyclosporine or amphotericin B Unknown Monitor renal function when Ganciclovir Injection is coadministered with cyclosporine or amphotericin B because of potential increase in serum creatinine [see Warnings and Precautions (5.2)]. (7) Cyclosporine or amphotericin B: When coadministered with ganciclovir, the risk of nephrotoxicity may be increased.
Amphotericin B Also Interacts With
- Cidofovir major
- Valganciclovir moderate
- Ketoconazole minor
- Anidulafungin minor
- Dexamethasone minor
Ganciclovir Also Interacts With
- Cyclosporine moderate
- Trimethoprim minor
- Probenecid minor
- Bictegravir/Emtricitabine/Tenofovir minor
- Emtricitabine/Tenofovir minor
Frequently Asked Questions
What SPL severity band is on file for Amphotericin B + Ganciclovir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amphotericin B has 12 labeled pairs on file vs Ganciclovir's 9. In the moderate band specifically: Amphotericin B has 2 (also Valganciclovir); Ganciclovir has 2 (also Cyclosporine).
What mechanism field is on file for Amphotericin B and Ganciclovir?
Both of these medications can be toxic to the kidneys when used at the same time. This combination may lead to a rise in serum creatinine levels, indicating kidney stress.
Amphotericin B carries more major-labeled pairs than Ganciclovir
SPL source-record counts only. This page's band is moderate · classes on file: Amphotericin B (Polyene Antifungal); Ganciclovir (Antiviral (Nucleoside Analog)).
Amphotericin B has 1 major-labeled pair vs Ganciclovir's 0. This page itself is in the moderate band, not the major band.
1 major · 2 moderate · 9 minor · 12 total
- Other moderate peers for Amphotericin B
- Valganciclovir
0 major · 2 moderate · 7 minor · 9 total
- Other moderate peers for Ganciclovir
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.