What the FDA labels say about taking them together
Alprazolam and erythromycin
Alprazolam's FDA label of January 18, 2023 names erythromycin in its drug interactions section, and erythromycin's label names alprazolam too. The erythromycin label: “Triazolobenzodiazepines and related benzodiazepines Erythromycin has been reported to decrease the clearance of triazolam and midazolam, and thus, may increase the pharmacologic effect of these benzodiazepines.”
Check it at the source: the alprazolam FDA label on DailyMed (effective January 18, 2023, PHARMACIA & UPJOHN COMPANY LLC); the erythromycin FDA label on DailyMed (effective August 1, 2024, Teva Pharmaceuticals USA, Inc.).
What does the alprazolam label say about erythromycin?
Alprazolam label, drug interactionsExamples; Nefazodone, fluvoxamine, cimetidine, erythromycin
Source: FDA drug label (Xanax), PHARMACIA & UPJOHN COMPANY LLC, effective January 18, 2023 (SPL set 388e249d-b9b6-44c3-9f8f-880eced0239f), via openFDA; the full label on DailyMed
What does the erythromycin label say about alprazolam?
Erythromycin label, drug interactionsTriazolobenzodiazepines (such as triazolam and alprazolam) and related benzodiazepines Erythromycin has been reported to decrease the clearance of triazolam and midazolam, and thus, may increase the pharmacologic effect of these benzodiazepines.
Source: FDA drug label (Erythromycin), Teva Pharmaceuticals USA, Inc., effective August 1, 2024 (SPL set 75a0bd5a-d09f-483b-bfd8-f8343b149eb2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alprazolam | Erythromycin | |
|---|---|---|
| Labeled for | Anxiety | Bacterial infections, Acne |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0236 per tablet 0.25 mg tablet | $1.96 per tablet 250 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once