Nirmatrelvir/Ritonavir and Trazodone Interaction
Drug interaction information between Nirmatrelvir/Ritonavir and Trazodone.
Nirmatrelvir/Ritonavir and Trazodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nirmatrelvir/Ritonavir and Trazodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paxlovid slows down the breakdown of trazodone in your system. This can cause higher drug levels and side effects like nausea, dizziness, or fainting.
FDA Label Information
trazodone ↑ trazodone Adverse reactions of nausea, dizziness, hypotension, and syncope have been observed following co-administration of trazodone and ritonavir. A lower dose of trazodone should be considered.
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Trazodone Also Interacts With
- Linezolid major
- Aspirin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Frequently Asked Questions
What SPL severity band is on file for Nirmatrelvir/Ritonavir + Trazodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Trazodone's 40. In the minor band specifically: Nirmatrelvir/Ritonavir has 33 (also Atorvastatin, Bupropion, Prednisone, Buspirone); Trazodone has 35 (also Tramadol, Buspirone, Clopidogrel, Rivaroxaban).
What mechanism field is on file for Nirmatrelvir/Ritonavir and Trazodone?
Paxlovid slows down the breakdown of trazodone in your system. This can cause higher drug levels and side effects like nausea, dizziness, or fainting.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Trazodone
SPL source-record counts only. This page's band is minor · classes on file: Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)); Trazodone (Serotonin Antagonist and Reuptake Inhibitor (SARI)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Trazodone's 1. This page itself is in the minor band, not the major band.
23 major · 30 moderate · 33 minor · 86 total
- Other minor peers for Nirmatrelvir/Ritonavir
- Atorvastatin
- Bupropion
- Prednisone
- Buspirone
1 major · 4 moderate · 35 minor · 40 total
- Other minor peers for Trazodone
- Tramadol
- Buspirone
- Clopidogrel
- Rivaroxaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.