Nirmatrelvir/Ritonavir and Lovastatin Interaction
Drug interaction information between Nirmatrelvir/Ritonavir and Lovastatin.
Nirmatrelvir/Ritonavir and Lovastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Nirmatrelvir/Ritonavir and Lovastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine blocks the way your body processes lovastatin, which can cause the drug to reach dangerous levels and hurt your muscles.
FDA Label Information
HMG-CoA reductase inhibitors lovastatin, simvastatin ↑ lovastatin ↑ simvastatin Co-administration contraindicated due to potential for myopathy including rhabdomyolysis [see Contraindications (4) ] . If treatment with PAXLOVID is considered medically necessary, discontinue use of lovastatin and simvastatin at least 12 hours prior to initiation of PAXLOVID, during the 5 days of PAXLOVID treatment, and for 5 days after completing PAXLOVID.
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
- Lurasidone major
Lovastatin Also Interacts With
- Darunavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
- Cyclosporine moderate
Frequently Asked Questions
What SPL severity band is on file for Nirmatrelvir/Ritonavir + Lovastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Lovastatin's 30. In the major band specifically: Nirmatrelvir/Ritonavir has 23 (also Simvastatin, Sildenafil, Carbamazepine, Rifampin); Lovastatin has 2 (also Darunavir).
What mechanism field is on file for Nirmatrelvir/Ritonavir and Lovastatin?
This medicine blocks the way your body processes lovastatin, which can cause the drug to reach dangerous levels and hurt your muscles.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Lovastatin
SPL source-record counts only. This page's band is major · classes on file: Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)); Lovastatin (HMG-CoA Reductase Inhibitor (Statin)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Lovastatin's 2.
23 major · 30 moderate · 33 minor · 86 total
- Other major peers for Nirmatrelvir/Ritonavir
- Simvastatin
- Sildenafil
- Carbamazepine
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.