Nirmatrelvir/Ritonavir and Simvastatin Interaction
Drug interaction information between Nirmatrelvir/Ritonavir and Simvastatin.
Nirmatrelvir/Ritonavir and Simvastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Nirmatrelvir/Ritonavir and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine stops your body from breaking down simvastatin, which can lead to high levels that cause serious muscle damage.
FDA Label Information
HMG-CoA reductase inhibitors lovastatin, simvastatin ↑ lovastatin ↑ simvastatin Co-administration contraindicated due to potential for myopathy including rhabdomyolysis [see Contraindications (4) ] . If treatment with PAXLOVID is considered medically necessary, discontinue use of lovastatin and simvastatin at least 12 hours prior to initiation of PAXLOVID, during the 5 days of PAXLOVID treatment, and for 5 days after completing PAXLOVID.
Nirmatrelvir/Ritonavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
- Lurasidone major
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Nirmatrelvir/Ritonavir + Simvastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Simvastatin's 41. In the major band specifically: Nirmatrelvir/Ritonavir has 23 (also Lovastatin, Sildenafil, Carbamazepine, Rifampin); Simvastatin has 11 (also Diltiazem, Verapamil, Cyclosporine, Amiodarone).
What mechanism field is on file for Nirmatrelvir/Ritonavir and Simvastatin?
This medicine stops your body from breaking down simvastatin, which can lead to high levels that cause serious muscle damage.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Simvastatin
SPL source-record counts only. This page's band is major · classes on file: Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Simvastatin's 11.
23 major · 30 moderate · 33 minor · 86 total
- Other major peers for Nirmatrelvir/Ritonavir
- Lovastatin
- Sildenafil
- Carbamazepine
- Rifampin
11 major · 9 moderate · 21 minor · 41 total
- Other major peers for Simvastatin
- Diltiazem
- Verapamil
- Cyclosporine
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.