Nirmatrelvir/Ritonavir and Bupropion Interaction
Drug interaction information between Nirmatrelvir/Ritonavir and Bupropion.
Nirmatrelvir/Ritonavir and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nirmatrelvir/Ritonavir and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paxlovid speeds up how fast your body gets rid of bupropion. This can make the medicine less effective because there is not enough of it in your blood.
FDA Label Information
Antidepressants bupropion ↓ bupropion and active metabolite hydroxy-bupropion Monitor for an adequate clinical response to bupropion.
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Nirmatrelvir/Ritonavir + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Bupropion's 35. In the minor band specifically: Nirmatrelvir/Ritonavir has 33 (also Atorvastatin, Trazodone, Prednisone, Buspirone); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel).
What mechanism field is on file for Nirmatrelvir/Ritonavir and Bupropion?
Paxlovid speeds up how fast your body gets rid of bupropion. This can make the medicine less effective because there is not enough of it in your blood.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Bupropion
SPL source-record counts only. This page's band is minor · classes on file: Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Bupropion's 1. This page itself is in the minor band, not the major band.
23 major · 30 moderate · 33 minor · 86 total
- Other minor peers for Nirmatrelvir/Ritonavir
- Atorvastatin
- Trazodone
- Prednisone
- Buspirone
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.