Nirmatrelvir/Ritonavir and Atorvastatin Interaction
Drug interaction information between Nirmatrelvir/Ritonavir and Atorvastatin.
Nirmatrelvir/Ritonavir and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nirmatrelvir/Ritonavir and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paxlovid blocks the enzymes that break down atorvastatin in your body. This causes the cholesterol medicine to build up to higher levels.
FDA Label Information
HMG-CoA reductase inhibitors atorvastatin ↑ atorvastatin Consider temporary discontinuation of atorvastatin during treatment with PAXLOVID. Atorvastatin does not need to be withheld prior to or after completing PAXLOVID.
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Nirmatrelvir/Ritonavir + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Atorvastatin's 36. In the minor band specifically: Nirmatrelvir/Ritonavir has 33 (also Bupropion, Trazodone, Prednisone, Buspirone); Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Erythromycin).
What mechanism field is on file for Nirmatrelvir/Ritonavir and Atorvastatin?
Paxlovid blocks the enzymes that break down atorvastatin in your body. This causes the cholesterol medicine to build up to higher levels.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Atorvastatin
SPL source-record counts only. This page's band is minor · classes on file: Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Atorvastatin's 3. This page itself is in the minor band, not the major band.
23 major · 30 moderate · 33 minor · 86 total
- Other minor peers for Nirmatrelvir/Ritonavir
- Bupropion
- Trazodone
- Prednisone
- Buspirone
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.