Warfarin and Atorvastatin Interaction
Drug interaction information between Warfarin and Atorvastatin.
Warfarin and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Warfarin and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Atorvastatin can slow down the liver enzymes that break down warfarin. This can cause warfarin to stay in your body longer and increase your risk of bleeding.
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Warfarin + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Atorvastatin's 36. In the minor band specifically: Warfarin has 133 (also Amlodipine, Omeprazole, Famotidine, Alprazolam); Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Erythromycin).
What mechanism field is on file for Warfarin and Atorvastatin?
Atorvastatin can slow down the liver enzymes that break down warfarin. This can cause warfarin to stay in your body longer and increase your risk of bleeding.
Atorvastatin carries more major-labeled pairs than Warfarin
SPL source-record counts only. This page's band is minor · classes on file: Warfarin (Vitamin K Antagonist (Anticoagulant)); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Atorvastatin has 3 major-labeled pairs vs Warfarin's 2. This page itself is in the minor band, not the major band.
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Amlodipine
- Omeprazole
- Famotidine
- Alprazolam
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.