Warfarin and Diclofenac Interaction
Drug interaction information between Warfarin and Diclofenac.
Warfarin and Diclofenac have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Warfarin and Diclofenac. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diclofenac is an anti-inflammatory medicine that can increase the risk of bleeding when used with warfarin. This combination makes it harder for your blood to clot properly.
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Desvenlafaxine moderate
Diclofenac Also Interacts With
- Misoprostol moderate
- Celecoxib minor
- Digoxin minor
- Fluconazole minor
- Indomethacin minor
Frequently Asked Questions
What SPL severity band is on file for Warfarin + Diclofenac?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Diclofenac's 11. In the moderate band specifically: Warfarin has 28 (also Ibuprofen, Aspirin, Desvenlafaxine, Vilazodone); Diclofenac has 2 (also Misoprostol).
What mechanism field is on file for Warfarin and Diclofenac?
Diclofenac is an anti-inflammatory medicine that can increase the risk of bleeding when used with warfarin. This combination makes it harder for your blood to clot properly.
Warfarin carries more major-labeled pairs than Diclofenac
SPL source-record counts only. This page's band is moderate · classes on file: Warfarin (Vitamin K Antagonist (Anticoagulant)); Diclofenac (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Warfarin has 2 major-labeled pairs vs Diclofenac's 0. This page itself is in the moderate band, not the major band.
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Ibuprofen
- Aspirin
- Desvenlafaxine
- Vilazodone
0 major · 2 moderate · 9 minor · 11 total
- Other moderate peers for Diclofenac
- Misoprostol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.