Warfarin and Diclofenac Interaction
Drug interaction information between Warfarin and Diclofenac.
Warfarin and Diclofenac have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Warfarin and Diclofenac. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Diclofenac is an anti-inflammatory medicine that can increase the risk of bleeding when used with warfarin. This combination makes it harder for your blood to clot properly.
What To Do
Avoid using these medications together unless your doctor specifically tells you to. If you must take both, watch closely for any signs of bleeding or bruising.
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Desvenlafaxine moderate
Diclofenac Also Interacts With
- Misoprostol moderate
- Celecoxib minor
- Digoxin minor
- Fluconazole minor
- Indomethacin minor
Frequently Asked Questions
Can I take Warfarin and Diclofenac together?
This is a moderate interaction. Avoid using these medications together unless your doctor specifically tells you to. If you must take both, watch closely for any signs of bleeding or bruising.
How serious is the interaction between Warfarin and Diclofenac?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Warfarin and Diclofenac interact?
Diclofenac is an anti-inflammatory medicine that can increase the risk of bleeding when used with warfarin. This combination makes it harder for your blood to clot properly.
Understanding the Warfarin and Diclofenac Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Warfarin belongs to the Vitamin K Antagonist (Anticoagulant) class and Diclofenac belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Diclofenac is an anti-inflammatory medicine that can increase the risk of bleeding when used with warfarin. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Warfarin has 163 total documented interactions on file in this dataset, and Diclofenac has 11. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid using these medications together unless your doctor specifically tells you to. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Warfarin or Diclofenac based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.