Atorvastatin and Erythromycin Interaction
Drug interaction information between Atorvastatin and Erythromycin.
Atorvastatin and Erythromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atorvastatin and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin slows down the process of clearing atorvastatin from your system, leading to higher drug levels.
FDA Label Information
Examples: Erythromycin, clarithromycin, itraconazole, ketoconazole, posaconazole, and voriconazole.
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Atorvastatin + Erythromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Atorvastatin's 36. In the minor band specifically: Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Rifampin); Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Bromocriptine, Buprenorphine).
What mechanism field is on file for Atorvastatin and Erythromycin?
Erythromycin slows down the process of clearing atorvastatin from your system, leading to higher drug levels.
Erythromycin carries more major-labeled pairs than Atorvastatin
SPL source-record counts only. This page's band is minor · classes on file: Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)); Erythromycin (Macrolide Antibiotic).
Erythromycin has 4 major-labeled pairs vs Atorvastatin's 3. This page itself is in the minor band, not the major band.
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Rifampin
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Bromocriptine
- Buprenorphine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.