Warfarin and Omeprazole Interaction
Drug interaction information between Warfarin and Omeprazole.
Warfarin and Omeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Warfarin and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Omeprazole blocks the liver enzymes that normally clear warfarin from your body. This can make the blood-thinning effect of warfarin stronger than intended.
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Frequently Asked Questions
What SPL severity band is on file for Warfarin + Omeprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Omeprazole's 27. In the minor band specifically: Warfarin has 133 (also Atorvastatin, Amlodipine, Famotidine, Alprazolam); Omeprazole has 22 (also Aripiprazole, Atomoxetine, Brexpiprazole, Carbamazepine).
What mechanism field is on file for Warfarin and Omeprazole?
Omeprazole blocks the liver enzymes that normally clear warfarin from your body. This can make the blood-thinning effect of warfarin stronger than intended.
Warfarin carries more major-labeled pairs than Omeprazole
SPL source-record counts only. This page's band is minor · classes on file: Warfarin (Vitamin K Antagonist (Anticoagulant)); Omeprazole (Proton Pump Inhibitor (PPI)).
Warfarin has 2 major-labeled pairs vs Omeprazole's 1. This page itself is in the minor band, not the major band.
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Famotidine
- Alprazolam
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Atomoxetine
- Brexpiprazole
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.