Warfarin and Amlodipine Interaction
Drug interaction information between Warfarin and Amlodipine.
Warfarin and Amlodipine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Warfarin and Amlodipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amlodipine can interfere with the way your liver processes warfarin. This can lead to higher levels of warfarin in your blood.
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
Frequently Asked Questions
What SPL severity band is on file for Warfarin + Amlodipine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Amlodipine's 15. In the minor band specifically: Warfarin has 133 (also Atorvastatin, Omeprazole, Famotidine, Alprazolam); Amlodipine has 10 (also Sildenafil, Cyclosporine, Amlodipine/Valsartan, Clarithromycin).
What mechanism field is on file for Warfarin and Amlodipine?
Amlodipine can interfere with the way your liver processes warfarin. This can lead to higher levels of warfarin in your blood.
Amlodipine carries more major-labeled pairs than Warfarin
SPL source-record counts only. This page's band is minor · classes on file: Warfarin (Vitamin K Antagonist (Anticoagulant)); Amlodipine (Calcium Channel Blocker).
Amlodipine has 4 major-labeled pairs vs Warfarin's 2. This page itself is in the minor band, not the major band.
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Omeprazole
- Famotidine
- Alprazolam
4 major · 1 moderate · 10 minor · 15 total
- Other minor peers for Amlodipine
- Sildenafil
- Cyclosporine
- Amlodipine/Valsartan
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.