Warfarin and Alprazolam Interaction
Drug interaction information between Warfarin and Alprazolam.
Warfarin and Alprazolam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Warfarin and Alprazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Alprazolam may slightly interfere with how your liver breaks down warfarin, which can affect your blood's ability to clot.
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Frequently Asked Questions
What SPL severity band is on file for Warfarin + Alprazolam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Alprazolam's 27. In the minor band specifically: Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine); Alprazolam has 20 (also Tramadol, Oxycodone, Morphine, Carbamazepine).
What mechanism field is on file for Warfarin and Alprazolam?
Alprazolam may slightly interfere with how your liver breaks down warfarin, which can affect your blood's ability to clot.
Warfarin carries more major-labeled pairs than Alprazolam
SPL source-record counts only. This page's band is minor · classes on file: Warfarin (Vitamin K Antagonist (Anticoagulant)); Alprazolam (Benzodiazepine).
Warfarin has 2 major-labeled pairs vs Alprazolam's 0. This page itself is in the minor band, not the major band.
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
0 major · 7 moderate · 20 minor · 27 total
- Other minor peers for Alprazolam
- Tramadol
- Oxycodone
- Morphine
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.