Verapamil and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Verapamil and Nirmatrelvir/Ritonavir.
Verapamil and Nirmatrelvir/Ritonavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Verapamil and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine slows down the breakdown of verapamil, which can cause the drug to stay in your system longer and reach higher levels. This happens because the antiviral interferes with a specific liver enzyme.
FDA Label Information
Calcium channel blockers amlodipine, diltiazem, felodipine, nicardipine, nifedipine, verapamil ↑ calcium channel blocker Caution is warranted and clinical monitoring of patients is recommended.
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Verapamil + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Verapamil's 57. In the moderate band specifically: Verapamil has 6 (also Clarithromycin, Lovastatin, Metoprolol, Midazolam); Nirmatrelvir/Ritonavir has 30 (also Amlodipine, Tamsulosin, Fluticasone, Apixaban).
What mechanism field is on file for Verapamil and Nirmatrelvir/Ritonavir?
This medicine slows down the breakdown of verapamil, which can cause the drug to stay in your system longer and reach higher levels. This happens because the antiviral interferes with a specific liver enzyme.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Verapamil
SPL source-record counts only. This page's band is moderate · classes on file: Verapamil (Calcium Channel Blocker); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Verapamil's 4. This page itself is in the moderate band, not the major band.
4 major · 6 moderate · 47 minor · 57 total
- Other moderate peers for Verapamil
- Clarithromycin
- Lovastatin
- Metoprolol
- Midazolam
23 major · 30 moderate · 33 minor · 86 total
- Other moderate peers for Nirmatrelvir/Ritonavir
- Amlodipine
- Tamsulosin
- Fluticasone
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.