Clarithromycin and Omeprazole Interaction
Drug interaction information between Clarithromycin and Omeprazole.
Clarithromycin and Omeprazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clarithromycin and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin slows down how your body processes omeprazole, which leads to higher levels of the stomach medicine in your system.
FDA Label Information
Proton Pump Inhibitors: Omeprazole No Dose Adjustment Omeprazole: The mean 24-hour gastric pH value was 5.2 when omeprazole was administered alone and 5.7 when coadministered with clarithromycin as a result of increased omeprazole exposures [see Pharmacokinetics ( 12.3 )] (see also Omeprazole under “Drugs That Affect Clarithromycin Tablets” in the table below). Saquinavir (in patients with normal renal function) Ritonavir (in patients with normal renal function) No Dose Adjustment Proton Pump Inhibitors: Omeprazole Use With Caution Omeprazole: Clarithromycin concentrations in the gastric...
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Omeprazole Also Interacts With
- Theophylline major
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
- Aripiprazole minor
Frequently Asked Questions
What SPL severity band is on file for Clarithromycin + Omeprazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Omeprazole's 27. In the moderate band specifically: Clarithromycin has 35 (also Methylprednisolone, Sildenafil, Valproate, Verapamil); Omeprazole has 4 (also Clopidogrel, Darunavir, Tacrolimus Topical).
What mechanism field is on file for Clarithromycin and Omeprazole?
Clarithromycin slows down how your body processes omeprazole, which leads to higher levels of the stomach medicine in your system.
Clarithromycin carries more major-labeled pairs than Omeprazole
SPL source-record counts only. This page's band is moderate · classes on file: Clarithromycin (Macrolide Antibiotic); Omeprazole (Proton Pump Inhibitor (PPI)).
Clarithromycin has 16 major-labeled pairs vs Omeprazole's 1. This page itself is in the moderate band, not the major band.
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Methylprednisolone
- Sildenafil
- Valproate
- Verapamil
1 major · 4 moderate · 22 minor · 27 total
- Other moderate peers for Omeprazole
- Clopidogrel
- Darunavir
- Tacrolimus Topical
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.