What the FDA labels say about taking them together
Clarithromycin and methylprednisolone
Clarithromycin's FDA label of April 9, 2026 names methylprednisolone in its drug interactions section; the methylprednisolone labels PlainMeds reads (3) do not name clarithromycin.
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the methylprednisolone FDA label on DailyMed (effective June 22, 2026, Mylan Pharmaceuticals Inc.).
What does the clarithromycin label say about methylprednisolone?
Clarithromycin label, drug interactionsOther Drugs Metabolized by CYP3A: Alfentanil Bromocriptine Cilostazol Methylprednisole Vinblastine Phenobarbital St. John’s Wort Use With Caution There have been spontaneous or published reports of CYP3A based interactions of clarithromycin with alfentanil, methylprednisolone, cilostazol, bromocriptine, vinblastine, phenobarbital, and St. John’s Wort.
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the methylprednisolone label say about clarithromycin?
Methylprednisolone's label (effective June 22, 2026) and its 2 other brand-application labels do not name clarithromycin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methylprednisolone), NDA011153 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective June 22, 2026 (SPL set 22dd75d6-f89a-44f7-8ca6-b64c4e9806dd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Methylprednisolone | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Osteoarthritis, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Asthma, Eczema (atopic dermatitis), Anemia |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | $0.121 per tablet 4 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once