Clarithromycin and Lurasidone Interaction
Drug interaction information between Clarithromycin and Lurasidone.
Clarithromycin and Lurasidone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Clarithromycin and Lurasidone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin stops the body from clearing lurasidone by blocking a specific enzyme, which can lead to toxic levels of the medication.
FDA Label Information
Colchicine (in patients with normal renal and hepatic function) Use With Caution Antipsychotics: Pimozide Contraindicated Pimozide: [See Contraindications ( 4.2 )] Quetiapine Lurasidone Quetiapine: Quetiapine is a substrate for CYP3A4, which is inhibited by clarithromycin. Lurasidone: [See Contraindications ( 4.7 )] Antispasmodics: Tolterodine (patients deficient in CYP2D6 activity) Use With Caution Tolterodine: The primary route of metabolism for tolterodine is via CYP2D6.
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Pimozide major
Lurasidone Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Clarithromycin + Lurasidone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Lurasidone's 15. In the major band specifically: Clarithromycin has 16 (also Quetiapine, Pioglitazone, Fluconazole, Cyclosporine); Lurasidone has 5 (also Darunavir, Itraconazole, Nirmatrelvir/Ritonavir, Voriconazole).
What mechanism field is on file for Clarithromycin and Lurasidone?
Clarithromycin stops the body from clearing lurasidone by blocking a specific enzyme, which can lead to toxic levels of the medication.
Clarithromycin carries more major-labeled pairs than Lurasidone
SPL source-record counts only. This page's band is major · classes on file: Clarithromycin (Macrolide Antibiotic); Lurasidone (Atypical Antipsychotic).
Clarithromycin has 16 major-labeled pairs vs Lurasidone's 5.
16 major · 35 moderate · 30 minor · 81 total
- Other major peers for Clarithromycin
- Quetiapine
- Pioglitazone
- Fluconazole
- Cyclosporine
5 major · 0 moderate · 10 minor · 15 total
- Other major peers for Lurasidone
- Darunavir
- Itraconazole
- Nirmatrelvir/Ritonavir
- Voriconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.