What the FDA labels say about taking them together
Clarithromycin and fluconazole
Clarithromycin's FDA label of April 9, 2026 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name clarithromycin. The clarithromycin label: “Fluconazole No Dose Adjustment Fluconazole:”
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the clarithromycin label say about fluconazole?
Clarithromycin label, drug interactionsFluconazole No Dose Adjustment Fluconazole: [see Pharmacokinetics (12.3) ]
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the fluconazole label say about clarithromycin?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name clarithromycin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Fluconazole | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Fungal infections, Urinary tract infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once