Clarithromycin and Fluconazole Interaction
Drug interaction information between Clarithromycin and Fluconazole.
Clarithromycin and Fluconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Clarithromycin and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not significantly affect each other's levels in the body.
FDA Label Information
Fluconazole No Dose Adjustment Fluconazole: [see Pharmacokinetics ( 12.3 )] Anti-Gout Agents: Colchicine (in patients with renal or hepatic impairment) Contraindicated Colchicine: Colchicine is a substrate for both CYP3A and the efflux transporter, P-glycoprotein (Pgp).
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Cyclosporine major
- Lurasidone major
- Pimozide major
Fluconazole Also Interacts With
- Pimozide major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
- Carbamazepine moderate
Frequently Asked Questions
What SPL severity band is on file for Clarithromycin + Fluconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Fluconazole's 67. In the major band specifically: Clarithromycin has 16 (also Quetiapine, Pioglitazone, Cyclosporine, Lurasidone); Fluconazole has 3 (also Pimozide, Eplerenone).
What mechanism field is on file for Clarithromycin and Fluconazole?
These two drugs do not significantly affect each other's levels in the body.
Clarithromycin carries more major-labeled pairs than Fluconazole
SPL source-record counts only. This page's band is major · classes on file: Clarithromycin (Macrolide Antibiotic); Fluconazole (Azole Antifungal).
Clarithromycin has 16 major-labeled pairs vs Fluconazole's 3.
16 major · 35 moderate · 30 minor · 81 total
- Other major peers for Clarithromycin
- Quetiapine
- Pioglitazone
- Cyclosporine
- Lurasidone
3 major · 7 moderate · 57 minor · 67 total
- Other major peers for Fluconazole
- Pimozide
- Eplerenone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.