Clarithromycin and Fluconazole Interaction
Drug interaction information between Clarithromycin and Fluconazole.
Clarithromycin and Fluconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Clarithromycin and Fluconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two drugs do not significantly affect each other's levels in the body.
What To Do
No dose adjustments are necessary when taking these medications at the same time.
FDA Label Information
Fluconazole No Dose Adjustment Fluconazole: [see Pharmacokinetics ( 12.3 )] Anti-Gout Agents: Colchicine (in patients with renal or hepatic impairment) Contraindicated Colchicine: Colchicine is a substrate for both CYP3A and the efflux transporter, P-glycoprotein (Pgp).
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Cyclosporine major
- Lurasidone major
- Pimozide major
Fluconazole Also Interacts With
- Pimozide major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
- Carbamazepine moderate
Frequently Asked Questions
Can I take Clarithromycin and Fluconazole together?
This is a major interaction. No dose adjustments are necessary when taking these medications at the same time.
How serious is the interaction between Clarithromycin and Fluconazole?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Clarithromycin and Fluconazole interact?
These two drugs do not significantly affect each other's levels in the body.
Understanding the Clarithromycin and Fluconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Clarithromycin belongs to the Macrolide Antibiotic class and Fluconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two drugs do not significantly affect each other's levels in the body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Clarithromycin has 81 total documented interactions on file in this dataset, and Fluconazole has 67. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No dose adjustments are necessary when taking these medications at the same time. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Clarithromycin or Fluconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.