Verapamil and Metoprolol Interaction
Drug interaction information between Verapamil and Metoprolol.
Verapamil and Metoprolol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Verapamil and Metoprolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both work to lower your heart rate and slow down the electrical conduction in your heart. Using them at the same time increases the risk of your heart rate becoming dangerously slow.
FDA Label Information
( 7.3 ) Concomitant use of glycosides, clonidine, and diltiazem and verapamil with beta-blockers can increase the risk of bradycardia. 7.4 Negative Chronotropes Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate.
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Fluoxetine minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Verapamil + Metoprolol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Metoprolol's 18. In the moderate band specifically: Verapamil has 6 (also Clarithromycin, Lovastatin, Midazolam, Nirmatrelvir/Ritonavir); Metoprolol has 3 (also Clonidine, Diltiazem).
What mechanism field is on file for Verapamil and Metoprolol?
These drugs both work to lower your heart rate and slow down the electrical conduction in your heart. Using them at the same time increases the risk of your heart rate becoming dangerously slow.
Verapamil carries more major-labeled pairs than Metoprolol
SPL source-record counts only. This page's band is moderate · classes on file: Verapamil (Calcium Channel Blocker); Metoprolol (Beta-Blocker).
Verapamil has 4 major-labeled pairs vs Metoprolol's 1. This page itself is in the moderate band, not the major band.
4 major · 6 moderate · 47 minor · 57 total
- Other moderate peers for Verapamil
- Clarithromycin
- Lovastatin
- Midazolam
- Nirmatrelvir/Ritonavir
1 major · 3 moderate · 14 minor · 18 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.