Clarithromycin and Valproate Interaction
Drug interaction information between Clarithromycin and Valproate.
Clarithromycin and Valproate have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clarithromycin and Valproate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin can change how your body processes valproate, which might lead to higher levels of the medicine in your system.
FDA Label Information
Other Drugs Metabolized by CYP450 Isoforms Other than CYP3A: Hexobarbital Phenytoin Valproate Use With Caution There have been postmarketing reports of interactions of clarithromycin with drugs not thought to be metabolized by CYP3A, including hexobarbital, phenytoin, and valproate.
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Valproate Also Interacts With
- Ranitidine major
- Cimetidine major
- Lidocaine Topical moderate
- Risperidone moderate
- Aspirin minor
Frequently Asked Questions
What SPL severity band is on file for Clarithromycin + Valproate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Valproate's 41. In the moderate band specifically: Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Verapamil); Valproate has 3 (also Lidocaine Topical, Risperidone).
What mechanism field is on file for Clarithromycin and Valproate?
Clarithromycin can change how your body processes valproate, which might lead to higher levels of the medicine in your system.
Clarithromycin carries more major-labeled pairs than Valproate
SPL source-record counts only. This page's band is moderate · classes on file: Clarithromycin (Macrolide Antibiotic); Valproate (Anticonvulsant / Mood Stabilizer).
Clarithromycin has 16 major-labeled pairs vs Valproate's 2. This page itself is in the moderate band, not the major band.
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Verapamil
2 major · 3 moderate · 36 minor · 41 total
- Other moderate peers for Valproate
- Lidocaine Topical
- Risperidone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.