Verapamil and Midazolam Interaction
Drug interaction information between Verapamil and Midazolam.
Verapamil and Midazolam have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Verapamil and Midazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Verapamil interferes with the liver enzyme responsible for clearing midazolam from your body. This causes the midazolam to stay in your blood for a longer period of time.
FDA Label Information
Other Drug Interactions Caution is advised when midazolam is administered concomitantly with drugs that are known to inhibit the P450-3A4 enzyme system such as cimetidine (not ranitidine), erythromycin, diltiazem, verapamil, ketoconazole and itraconazole. The effects of diltiazem (60 mg tid) and verapamil (80 mg tid) on the pharmacokinetics and pharmacodynamics of midazolam were investigated in a three-way crossover study (n=9). The half-life of midazolam increased from 5 to 7 hours when midazolam was taken in conjunction with verapamil or diltiazem.
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Midazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Erythromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Verapamil + Midazolam?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Midazolam's 39. In the moderate band specifically: Verapamil has 6 (also Clarithromycin, Lovastatin, Metoprolol, Nirmatrelvir/Ritonavir); Midazolam has 9 (also Ketoconazole, Erythromycin, Ranitidine, Cimetidine).
What mechanism field is on file for Verapamil and Midazolam?
Verapamil interferes with the liver enzyme responsible for clearing midazolam from your body. This causes the midazolam to stay in your blood for a longer period of time.
Verapamil carries more major-labeled pairs than Midazolam
SPL source-record counts only. This page's band is moderate · classes on file: Verapamil (Calcium Channel Blocker); Midazolam (Benzodiazepine).
Verapamil has 4 major-labeled pairs vs Midazolam's 3. This page itself is in the moderate band, not the major band.
4 major · 6 moderate · 47 minor · 57 total
- Other moderate peers for Verapamil
- Clarithromycin
- Lovastatin
- Metoprolol
- Nirmatrelvir/Ritonavir
3 major · 9 moderate · 27 minor · 39 total
- Other moderate peers for Midazolam
- Ketoconazole
- Erythromycin
- Ranitidine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.