What the FDA labels say about taking them together
Clarithromycin and sildenafil
Clarithromycin's FDA label of April 9, 2026 names sildenafil in its drug interactions section; the sildenafil labels PlainMeds reads (4) do not name clarithromycin.
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the sildenafil FDA label on DailyMed (effective November 17, 2023, Viatris Specialty LLC).
What does the clarithromycin label say about sildenafil?
Clarithromycin label, drug interactionsPhosphodiesterase inhibitors: Sildenafil Tadalafil Vardenafil Use With Caution Sildenafil, Tadalafil, Vardenafil:
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the sildenafil label say about clarithromycin?
Sildenafil's label (effective November 17, 2023) and its 3 other brand-application labels do not name clarithromycin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Viagra), Viatris Specialty LLC, effective November 17, 2023 (SPL set d905dc8d-917f-4ea3-a4ee-a1ecf6967d4e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Sildenafil | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Erectile dysfunction, Pulmonary arterial hypertension |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | $0.132 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once