Clarithromycin and Sildenafil Interaction
Drug interaction information between Clarithromycin and Sildenafil.
Clarithromycin and Sildenafil have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clarithromycin and Sildenafil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin stops your body from breaking down sildenafil normally, which can lead to higher and potentially unsafe levels of the drug in your blood.
FDA Label Information
Phosphodiesterase inhibitors: Sildenafil Tadalafil Vardenafil Use With Caution Sildenafil, Tadalafil, Vardenafil: Each of these phosphodiesterase inhibitors is primarily metabolized by CYP3A, and CYP3A will be inhibited by concomitant administration of clarithromycin. Co-administration of clarithromycin with sildenafil, tadalafil, or vardenafil will result in increased exposure of these phosphodiesterase inhibitors.
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Sildenafil Also Interacts With
- Ketoconazole major
- Erythromycin major
- Itraconazole major
- Darunavir major
- Hydralazine/Isosorbide Dinitrate major
Frequently Asked Questions
What SPL severity band is on file for Clarithromycin + Sildenafil?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Sildenafil's 10. In the moderate band specifically: Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Valproate, Verapamil); Sildenafil has 1.
What mechanism field is on file for Clarithromycin and Sildenafil?
Clarithromycin stops your body from breaking down sildenafil normally, which can lead to higher and potentially unsafe levels of the drug in your blood.
Clarithromycin carries more major-labeled pairs than Sildenafil
SPL source-record counts only. This page's band is moderate · classes on file: Clarithromycin (Macrolide Antibiotic); Sildenafil (PDE5 Inhibitor).
Clarithromycin has 16 major-labeled pairs vs Sildenafil's 6. This page itself is in the moderate band, not the major band.
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Valproate
- Verapamil
6 major · 1 moderate · 3 minor · 10 total
Sildenafil has no other moderate-band peer in this dataset besides Clarithromycin.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.