Vasopressin and Itraconazole Interaction
Drug interaction information between Vasopressin and Itraconazole.
Vasopressin and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vasopressin and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole slows down the process of clearing these medicines from your body. This can lead to higher amounts of the drug in your system and a higher risk of side effects.
FDA Label Information
Vasopressin Receptor Antagonists Conivaptan Tolvaptan Not recommended during and 2 weeks after itraconazole treatment.
Vasopressin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Lithium minor
- Enalapril minor
- Haloperidol minor
- Clozapine minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Vasopressin + Itraconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Vasopressin's 9. In the moderate band specifically: Vasopressin has 1; Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Tenofovir Disoproxil, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Vasopressin and Itraconazole?
Itraconazole slows down the process of clearing these medicines from your body. This can lead to higher amounts of the drug in your system and a higher risk of side effects.
Itraconazole carries more major-labeled pairs than Vasopressin
SPL source-record counts only. This page's band is moderate · classes on file: Vasopressin (Vasopressin Receptor Agonist); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Vasopressin's 1. This page itself is in the moderate band, not the major band.
1 major · 1 moderate · 7 minor · 9 total
Vasopressin has no other moderate-band peer in this dataset besides Itraconazole.
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Tenofovir Disoproxil
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.