Vasopressin and Haloperidol Interaction
Drug interaction information between Vasopressin and Haloperidol.
Vasopressin and Haloperidol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Vasopressin and Haloperidol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Haloperidol may cause the body to keep too much water, which makes the effects of vasopressin stronger. This can increase blood pressure and water buildup in the body.
FDA Label Information
7.4 Drugs Suspected of Causing SIADH Use with drugs suspected of causing SIADH (e.g., SSRIs, tricyclic antidepressants, haloperidol, chlorpropamide, enalapril, methyldopa, pentamidine, vincristine, cyclophosphamide, ifosfamide, felbamate) may increase the pressor effect in addition to the antidiuretic effect of Vasopressin injection.
Vasopressin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Itraconazole moderate
- Lithium minor
- Enalapril minor
- Clozapine minor
Haloperidol Also Interacts With
- Fluoxetine moderate
- Tetrabenazine moderate
- Bromocriptine minor
- Bupropion minor
- Carbamazepine minor
Frequently Asked Questions
What SPL severity band is on file for Vasopressin + Haloperidol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Haloperidol has 14 labeled pairs on file vs Vasopressin's 9. In the minor band specifically: Vasopressin has 7 (also Lithium, Enalapril, Clozapine, Methyldopa); Haloperidol has 12 (also Bromocriptine, Bupropion, Carbamazepine, Clomipramine).
What mechanism field is on file for Vasopressin and Haloperidol?
Haloperidol may cause the body to keep too much water, which makes the effects of vasopressin stronger. This can increase blood pressure and water buildup in the body.
Vasopressin carries more major-labeled pairs than Haloperidol
SPL source-record counts only. This page's band is minor · classes on file: Vasopressin (Vasopressin Receptor Agonist); Haloperidol (Typical Antipsychotic).
Vasopressin has 1 major-labeled pair vs Haloperidol's 0. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 7 minor · 9 total
- Other minor peers for Vasopressin
- Lithium
- Enalapril
- Clozapine
- Methyldopa
0 major · 2 moderate · 12 minor · 14 total
- Other minor peers for Haloperidol
- Bromocriptine
- Bupropion
- Carbamazepine
- Clomipramine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.