Vasopressin and Lithium Interaction
Drug interaction information between Vasopressin and Lithium.
Vasopressin and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Vasopressin and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lithium can block the effects of vasopressin, making it less able to raise blood pressure or manage water levels.
FDA Label Information
7.5 Drugs Suspected of Causing Diabetes Insipidus Use with drugs suspected of causing diabetes insipidus (e.g., demeclocycline, lithium, foscarnet, clozapine) may decrease the pressor effect in addition to the antidiuretic effect of Vasopressin injection.
Vasopressin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Itraconazole moderate
- Enalapril minor
- Haloperidol minor
- Clozapine minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Vasopressin + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Vasopressin's 9. In the minor band specifically: Vasopressin has 7 (also Enalapril, Haloperidol, Clozapine, Methyldopa); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Vasopressin and Lithium?
Lithium can block the effects of vasopressin, making it less able to raise blood pressure or manage water levels.
Lithium carries more major-labeled pairs than Vasopressin
SPL source-record counts only. This page's band is minor · classes on file: Vasopressin (Vasopressin Receptor Agonist); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Vasopressin's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 7 minor · 9 total
- Other minor peers for Vasopressin
- Enalapril
- Haloperidol
- Clozapine
- Methyldopa
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.