Vasopressin and Enalapril Interaction
Drug interaction information between Vasopressin and Enalapril.
Vasopressin and Enalapril have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Vasopressin and Enalapril. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Enalapril can cause the body to hold onto more water, which adds to the effects of vasopressin. This can lead to higher blood pressure and more water retention.
FDA Label Information
7.4 Drugs Suspected of Causing SIADH Use with drugs suspected of causing SIADH (e.g., SSRIs, tricyclic antidepressants, haloperidol, chlorpropamide, enalapril, methyldopa, pentamidine, vincristine, cyclophosphamide, ifosfamide, felbamate) may increase the pressor effect in addition to the antidiuretic effect of Vasopressin injection.
Vasopressin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Itraconazole moderate
- Lithium minor
- Haloperidol minor
- Clozapine minor
Enalapril Also Interacts With
- Aliskiren major
- Spironolactone minor
- Hydralazine minor
- Lithium minor
- Prazosin minor
Frequently Asked Questions
What SPL severity band is on file for Vasopressin + Enalapril?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Enalapril has 16 labeled pairs on file vs Vasopressin's 9. In the minor band specifically: Vasopressin has 7 (also Lithium, Haloperidol, Clozapine, Methyldopa); Enalapril has 15 (also Spironolactone, Hydralazine, Lithium, Prazosin).
What mechanism field is on file for Vasopressin and Enalapril?
Enalapril can cause the body to hold onto more water, which adds to the effects of vasopressin. This can lead to higher blood pressure and more water retention.
Enalapril's labeled portfolio outnumbers Vasopressin
SPL source-record counts only. This page's band is minor · classes on file: Vasopressin (Vasopressin Receptor Agonist); Enalapril (ACE Inhibitor).
1 major · 1 moderate · 7 minor · 9 total
- Other minor peers for Vasopressin
- Lithium
- Haloperidol
- Clozapine
- Methyldopa
1 major · 0 moderate · 15 minor · 16 total
- Other minor peers for Enalapril
- Spironolactone
- Hydralazine
- Lithium
- Prazosin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.