What the FDA labels say about taking them together
Clozapine and vasopressin
Vasopressin's FDA label of February 21, 2025 names clozapine in its drug interactions section; the clozapine labels PlainMeds reads (2) do not name vasopressin. The vasopressin label: “Suspected of Causing Diabetes Insipidus Use with drugs suspected of causing diabetes insipidus may decrease the pressor effect in addition to the antidiuretic effect of Vasostrict ®.”
Check it at the source: the clozapine FDA label on DailyMed (effective June 6, 2025, HLS Therapeutics (USA), Inc.); the vasopressin FDA label on DailyMed (effective February 21, 2025, Baxter Healthcare Corporation).
What does the clozapine label say about vasopressin?
Clozapine's label (effective June 6, 2025) and its 1 other brand-application label do not name vasopressin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clozaril), NDA019758 (Heritage Life), as published by HLS Therapeutics (USA), Inc., effective June 6, 2025 (SPL set 90876802-0e3a-44c9-9ff7-1754dfbe736a), via openFDA; the full label on DailyMed
What does the vasopressin label say about clozapine?
Vasopressin label, drug interactionsSuspected of Causing Diabetes Insipidus Use with drugs suspected of causing diabetes insipidus (e.g., demeclocycline, lithium, foscarnet, clozapine) may decrease the pressor effect in addition to the antidiuretic effect of Vasopressin in Sodium Chloride Injection.
Source: FDA drug label (Vasostrict, NDA204485), Par Health USA, LLC, effective April 21, 2026 (SPL set b1147beb-743e-4c62-8927-91192447f8b8), via openFDA
Source: FDA drug label (Vasopressin, NDA212593), American Regent, Inc., effective October 31, 2024 (SPL set 0ab267f4-9ec9-44fd-8521-f975074667d9), via openFDA
Source: FDA drug label (Vasopressin in 0.9% Sodium Chloride), Baxter Healthcare Corporation, effective February 21, 2025 (SPL set b5b2c367-6b7e-40be-a296-c4632f3e783f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clozapine | Vasopressin | |
|---|---|---|
| Labeled for | Schizophrenia | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.610 per tablet 100 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once