Vasopressin and Clozapine Interaction
Drug interaction information between Vasopressin and Clozapine.
Vasopressin and Clozapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Vasopressin and Clozapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clozapine can interfere with how the body processes water, which makes vasopressin less effective. This can result in lower blood pressure and less water retention than expected.
FDA Label Information
7.5 Drugs Suspected of Causing Diabetes Insipidus Use with drugs suspected of causing diabetes insipidus (e.g., demeclocycline, lithium, foscarnet, clozapine) may decrease the pressor effect in addition to the antidiuretic effect of Vasopressin injection.
Vasopressin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Itraconazole moderate
- Lithium minor
- Enalapril minor
- Haloperidol minor
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
Frequently Asked Questions
What SPL severity band is on file for Vasopressin + Clozapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Vasopressin's 9. In the minor band specifically: Vasopressin has 7 (also Lithium, Enalapril, Haloperidol, Methyldopa); Clozapine has 39 (also Sertraline, Escitalopram, Bupropion, Duloxetine).
What mechanism field is on file for Vasopressin and Clozapine?
Clozapine can interfere with how the body processes water, which makes vasopressin less effective. This can result in lower blood pressure and less water retention than expected.
Vasopressin carries more major-labeled pairs than Clozapine
SPL source-record counts only. This page's band is minor · classes on file: Vasopressin (Vasopressin Receptor Agonist); Clozapine (Atypical Antipsychotic).
Vasopressin has 1 major-labeled pair vs Clozapine's 0. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 7 minor · 9 total
- Other minor peers for Vasopressin
- Lithium
- Enalapril
- Haloperidol
- Methyldopa
0 major · 3 moderate · 39 minor · 42 total
- Other minor peers for Clozapine
- Sertraline
- Escitalopram
- Bupropion
- Duloxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.