Itraconazole and Tenofovir Disoproxil Interaction
Drug interaction information between Itraconazole and Tenofovir Disoproxil.
Itraconazole and Tenofovir Disoproxil have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Itraconazole and Tenofovir Disoproxil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole can cause tenofovir levels to increase by changing how the body handles the drug.
FDA Label Information
Elbasvir/grazoprevir Glecaprevir/pibrentasvir Tenofovir disoproxil fumarate Not recommended during and 2 weeks after itraconazole treatment.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Tenofovir Disoproxil Also Interacts With
- Valacyclovir minor
- Acyclovir minor
- Gentamicin minor
- Darunavir minor
- Ledipasvir/Sofosbuvir minor
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Tenofovir Disoproxil?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Tenofovir Disoproxil's 14. In the moderate band specifically: Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Glecaprevir/Pibrentasvir, Aliskiren); Tenofovir Disoproxil has 1.
What mechanism field is on file for Itraconazole and Tenofovir Disoproxil?
Itraconazole can cause tenofovir levels to increase by changing how the body handles the drug.
Itraconazole carries more major-labeled pairs than Tenofovir Disoproxil
SPL source-record counts only. This page's band is moderate · classes on file: Itraconazole (Azole Antifungal); Tenofovir Disoproxil (Nucleotide Reverse Transcriptase Inhibitor).
Itraconazole has 19 major-labeled pairs vs Tenofovir Disoproxil's 0. This page itself is in the moderate band, not the major band.
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Glecaprevir/Pibrentasvir
- Aliskiren
0 major · 1 moderate · 13 minor · 14 total
Tenofovir Disoproxil has no other moderate-band peer in this dataset besides Itraconazole.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.