What the FDA labels say about taking them together
Itraconazole and tenofovir disoproxil
Itraconazole's FDA label of July 13, 2026 names tenofovir disoproxil in its drug interactions section; the tenofovir disoproxil labels PlainMeds reads (2) do not name itraconazole. The itraconazole label: “See also Table 5. Tenofovir disoproxil fumarate Monitor for adverse reactions. Beta Blockers Nadolol Monitor for adverse reactions.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the tenofovir disoproxil FDA label on DailyMed (effective June 7, 2024, Aurobindo Pharma Limited).
What does the itraconazole label say about tenofovir disoproxil?
Itraconazole label, drug interactionsElbasvir/grazoprevir Not recommended during and 2 weeks after SPORANOX ® treatment. Glecaprevir/pibrentasvir Monitor for adverse reactions. Tenofovir disoproxil fumarate Monitor for adverse reactions. Beta Blockers Nadolol Monitor for adverse reactions.
Tolsura label (Mayne Pharma Commercial LLC, April 23, 2025), drug interactionsSee also Table 5 . Tenofovir disoproxil fumarate Monitor for adverse reactions. Beta Blockers Nadolol Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the tenofovir disoproxil label say about itraconazole?
Tenofovir disoproxil's label (effective June 7, 2024) and its 1 other brand-application label do not name itraconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tenofovir Disoproxil Fumarate), Aurobindo Pharma Limited, effective June 7, 2024 (SPL set a75c6be8-3719-4bb3-8a9e-06e5254d2a82), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Tenofovir disoproxil | |
|---|---|---|
| Labeled for | Fungal infections | HIV, Hepatitis B |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $0.294 per tablet 300 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once